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KMID : 0388219940010020213
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Journal of the Korean Rheumatism Association
1994 Volume.1 No. 2 p.213 ~ p.220
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The Histochemical Distribution of Collagen in the Osteoarthritic Human Cartilage
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배상철
정성수/이인홍/유대현/김성윤/정현기/최일용
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Abstract
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Objective :
@EN Osteoarthritis is a disoreder or group of disorders affecting synovial joint, characterized at the tissue level by degenerative, regenerative and reparative structural changes in crtilage, synovium and bone. The histopathological
understanding
of
ostecarthritis would help to clear the pathogenesis and evaluate the activity and progression of the disease. We studied the histochemical distribution of collagen in the search for and accurate morphometric marker for osteoarthritic progression.
@ES methods :
@EN The immunohistochemical analysis by monoclonal antibodies to type I, Ii and III collagen, the Masson's trichrome stain and the Picrosirius stain and polarization mucroscopy were performed in 10 osteoarthritis cartilages and 1 normal control
cartilage.
@ES Results :
@EN 1) By the immunohistochemical analysis, type II collagen was diffusely expreessed in both normal and osteoarthritis cartilage but the expression of type I and III collagen was only shown around chondrocytes in the osteoarthritis cartilage.
2) There was no difference in Masson's trichrome stain of the normal and osteoarthritis cartilage.
3) By the Picrosirius stain and polarization microscopy, there was less diffuse bireffringence of collagen and increased perichondronal birefringence in the osteoarthritis cartilage in comparison to normal cartilage.
@ES Conclusion :
@EN The Picrosirius-polarization method may be considered one of the use ful morphometriic methods for the progression of osteoarthrits.
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KEYWORD
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